According to a recent article in the Journal of the American Medical Association (JAMA), chronic diseases account for 75% of health care expenditures. Ironically, most of these chronic diseases have proven modifiable risk factors. In fact, 4 health behaviors (smoking, diet, physical activity, and alcohol) are directly related to development of these chronic diseases, or avoidance of these chronic diseases. While most Americans await the latest biomedical advances to address these health behavior issues, simple lifestyle modification provides far more success. A glaring example of this is seen by the fact that a new diabetes or anti-obesity drug can make headlines if it reduces glycohemoglobin levels or body weight by 0.5%. In contrast, exercise can lower the incidence of diabetes by 50%, and appropriate diet modification can have dramatic effects on weight loss. Yes, Benjamin Franklin was right! It is still as true today as it was over 200 years ago: “An ounce of prevention is worth a pound of cure”. And the corollary is: Prevention is not something that we can have done for us by a  professional, nor is it something that works well by avoiding lifestyle change and using medications and supplements and medical procedures to address the symptoms. We all have the power within us to positively modify our health now and more importantly, to avoid the development of most chronic diseases in our future.